Phosphatidylserine is a popular dietary supplement that is used to improve mental concentration, memory and mood and stress. It is a phospholipid, a fat molecule bound to phosphate, a major component of cell membranes. Read on to learn more about the health benefits of this supplement in our Phosphatidylserine wiki, potential side effects and optimal dosages.
It is of special importance for brain function and people use it as a supplement to improve cognitive function, memory, stress reduction and more . Phosphatidylserine (abbreviated as PTD, L-Ser or PS) is a phospholipid, a component of all membranes in cell membranes. It is the phospholipside of glycerophospholipids, consisting of two fatty acids bound by ester compounds to the first and second carbon of the glycerol, while serine is bound by a phosphodiester compound to the third carbon in the glycerol.
Phosphatidylserine (PS) is derived from phospholipids from the bovine brain and was shown to improve memory, cognition and mood in elderly in two placebo-controlled studies. Phosphatides are extracted from plants and differ in the composition of fatty acids from those of animals. Although it is widely used, it belongs to a special category of fat-soluble substances, phospholipsides, which are important components of cell membranes.
Study on Phosphatidylserine
In an open-label study with ten older women with depressive disorders, supplementation with PS after 30 days of treatment resulted in consistent improvement of depressive symptoms, memory and behavior. A double-blind study of 494 geriatric patients with cognitive impairment revealed that 300 mg PS / day resulted in significant improvements in behavioral and cognitive parameters at three and six months. The authors concluded that 600 mg / d PS daily for 10 days promoted favorable hormone status training in these individuals.
According to a report published in Sports Medicine in 2006, phosphatidylserine supplements can help increase physical activity and improve athletic performance. In one study, adding neurotransmitters with phosphatidlyserine (100 mg) three times a day improved the mood and mental function of Parkinson’s Disease patients and exerted positive effects on muscle control. Previous research has shown that plant phosphate supplements can offer some benefits, such as a 2010 study on memory with soy-based phosphate IDylserins, but more research is needed.
Large, well-designed clinical studies are needed to confirm the promising positive effects of phosphatidylserine on Alzheimer’s disease. Small studies have shown some benefits, but there is a lack of good human research to support many claims about this supplement. It does not appear to be the current focus of research, suggesting it could have limited effects.
Phosphatidylserine in combination with omega-3 fatty acids reduced the symptoms of Alzheimer’s disease in two clinical studies in 236 children aged 6 to 20 years. According to the authors of a study, it was also effective in hyperactive, impulsive and dysregulated Alzheimer’s disease in children . Despite the cognitive benefits of phosphatidol, it is often sold to people who believe they can benefit from increased intake as a dietary supplement.
Out of concern about mad cow disease, most manufacturers produce phosphatidylserine preparations from soya or cabbage derivatives. One supplement that promotes the recovery of phosphatidsylserines is P.S.
Research on PS has shown that it can improve mood, performance recovery, immunity, decision-making accuracy and cognition [8,11,18,19,24,33]. Research on PS also shows that it has the unique property of lowering cortisol levels after exercise [22.214.171.124], which leads to an improved testosterone-cortisol ratio .
PS is an amino acid (L-serine) that is bonded to its phosphate ester group , and in high concentrations occurs in organs with high metabolic requirements (heart, lung, brain, liver and skeletal muscle) . A unique attribute of PS is its ability to blunt cortisol [81.129.30,36] and improve testosterone and cortisol levels , which provides a favorable hormonal status for exercising individuals. To facilitate detection, the ACS externalizes phosphatidylserine (PS) from the inner to outer shell of its cell membrane to facilitate phagocytes to emit an “eat me” signal.
Several receptors expressed by phagocytes have shown bind to PS, which is exposed to dying cells, and contribute to its uptake (Fig. In Scott syndrome, platelet-deficient PS exposure and activation pathology (phosphatidylserine exposure and deficient EV formation) is associated with the release of membrane-binding EVs (also called microparticles, microvesicles, platelets or plasma membranes) ; e.g. Albacker and colleagues have shown that TIM4 regulates immune tolerance and memory maintenance in T cell populations by excluding active antigen-specific T cells during the immune-tolerant phase and by expressing intermediate levels of phosphatidlyserine (PS) that can be removed with less efficiency than ACS in addition to maintaining the homeostasis and phagocytosis of ACS.